Cargando…

Design, synthesis, in vitro anti-α-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents

An important target in the treatment of type 2 diabetes is α-glucosidase. Inhibition of this enzyme led to delay in glucose absorption and decrease in postprandial hyperglycemia. A new series of phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides 11a–n were designed based on the repor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Emadi, Mehdi, Halimi, Mohammad, Moazzam, Ali, Hosseini, Samanesadat, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Ghadimi, Reza, Moghadamnia, Ali Akbar, Nasli-Esfahani, Ensieh, Mohammadi-Khanaposhtani, Maryam, Mahdavi, Mohammad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282079/ https://www.ncbi.nlm.nih.gov/pubmed/37340010 http://dx.doi.org/10.1038/s41598-023-36890-y

Ejemplares similares

Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: design, synthesis, in vitro α-glucosidase inhibition, and computational studies
por: Emadi, Mehdi, et al.
Publicado: (2023)

Synthesis, ADMT prediction, and in vitro and in silico α-glucosidase inhibition evaluations of new quinoline–quinazolinone–thioacetamides
por: Safapoor, Sajedeh, et al.
Publicado: (2023)

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors
por: Nasli Esfahani, Anita, et al.
Publicado: (2021)

Docking study, molecular dynamic, synthesis, anti-α-glucosidase assessment, and ADMET prediction of new benzimidazole-Schiff base derivatives
por: Azizian, Homa, et al.
Publicado: (2022)

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents
por: Niri, Davood Rezapour, et al.
Publicado: (2022)

Design, synthesis, in vitro α-glucosidase inhibition, docking, and molecular dynamics of new phthalimide-benzenesulfonamide hybrids for targeting type 2 diabetes
por: Askarzadeh, Mohammad, et al.
Publicado: (2022)

Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors
por: Noori, Milad, et al.
Publicado: (2022)

Design, synthesis, in vitro, and in silico evaluations of benzo[d]imidazole-amide-1,2,3-triazole-N-arylacetamide hybrids as new antidiabetic agents targeting α-glucosidase
por: Yousefnejad, Faeze, et al.
Publicado: (2023)

Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors
por: Pedrood, Keyvan, et al.
Publicado: (2022)

Novel Pyrano[3,2-c]quinoline-1,2,3-triazole Hybrids as Potential Anti-Diabetic Agents: In Vitro α-Glucosidase Inhibition, Kinetic, and Molecular Dynamics Simulation
por: Esmaili, Soheila, et al.
Publicado: (2023)

One-pot multi-component synthesis of novel chromeno[4,3-b]pyrrol-3-yl derivatives as alpha-glucosidase inhibitors
por: Karami, Malihe, et al.
Publicado: (2021)

Synthesis, in vitro α-glucosidase inhibitory activities, and molecular dynamic simulations of novel 4-hydroxyquinolinone-hydrazones as potential antidiabetic agents
por: Shayegan, Nahal, et al.
Publicado: (2023)

Anticancer, Anti-Inflammatory, and Analgesic Activities of Synthesized 2-(Substituted phenoxy) Acetamide Derivatives
por: Rani, Priyanka, et al.
Publicado: (2014)

Cyanoacetohydrazide linked to 1,2,3-triazole derivatives: a new class of α-glucosidase inhibitors
por: Iraji, Aida, et al.
Publicado: (2022)

Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors
por: Moheb, Mahshid, et al.
Publicado: (2022)

Novel N′-substituted benzylidene benzohydrazides linked to 1,2,3-triazoles: potent α-glucosidase inhibitors
por: Saeedi, Mina, et al.
Publicado: (2023)

Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors
por: Moghadam Farid, Sara, et al.
Publicado: (2023)

Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α-glucosidase inhibitors
por: Forozan, RasaDokht, et al.
Publicado: (2023)

Chemical composition, cholinesterase, and α-glucosidase inhibitory activity of the essential oils of some Iranian native Salvia species
por: Gharehbagh, Houra Jazayeri, et al.
Publicado: (2023)

An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity
por: Peytam, Fariba, et al.
Publicado: (2020)

Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides
por: Pedrood, Keyvan, et al.
Publicado: (2023)

N-Sulfenylsuccinimide/phthalimide: an alternative sulfenylating reagent in organic transformations
por: Doraghi, Fatemeh, et al.
Publicado: (2023)

Diabetes management during Ramadan amid Covid-19 pandemic
por: Tootee, Ali, et al.
Publicado: (2020)

Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
por: Sohrabi, Marzieh, et al.
Publicado: (2022)

Osmolyte-Induced Folding and Stability of Proteins: Concepts and Characterization
por: Mojtabavi, Somayeh, et al.
Publicado: (2019)

1, 5-dicaffeoylquinic acid, an α-glucosidase inhibitor from the root of Dorema ammoniacum D. Don
por: Etemadi-Tajbakhsh, Nikdokht, et al.
Publicado: (2020)

Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor
por: Azimi, Fateme, et al.
Publicado: (2021)

Synthesis and Evaluation of the Anxiolytic Activity of Some Phthalimide Derivatives in Mice Model of Anxiety
por: Hassanzadeh, Farshid, et al.
Publicado: (2012)

Mechanisms involved in altered bone metabolism in diabetes: a narrative review
por: Ghodsi, Maryam, et al.
Publicado: (2016)

Anti-Hyperuricemic, Anti-Arthritic, Hemolytic Activity and Therapeutic Safety of Glycoconjugated Triazole-Phthalimides
por: da Silva, José Guedes, et al.
Publicado: (2023)

Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase
por: Peytam, Fariba, et al.
Publicado: (2021)

N-(4-Methoxyphenyl)phthalimide
por: Sim, Yoke Ling, et al.
Publicado: (2009)

N-(2-Methoxyphenyl)phthalimide
por: Sim, Yoke Ling, et al.
Publicado: (2009)

Design, Synthesis and Evaluation of Novel Phthalimide Derivatives as in Vitro Anti-Microbial, Anti-Oxidant and Anti-Inflammatory Agents
por: F. Lamie, Phoebe, et al.
Publicado: (2015)

An efficient synthesis of 4-phenoxy-quinazoline, 2-phenoxy-quinoxaline, and 2-phenoxy-pyridine derivatives using aryne chemistry
por: Zilla, Mahesh K., et al.
Publicado: (2021)

The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-γ Agonist
por: Su, Mingzhi, et al.
Publicado: (2017)

Computational modeling and synthesis of Pyridine variants of Benzoyl-Phenoxy-Acetamide with high glioblastoma cytotoxicity and brain tumor penetration
por: Ingraham IV, Charles, et al.
Publicado: (2023)

Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration
por: Ingraham, Charles H., et al.
Publicado: (2023)

Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies
por: Peytam, Fariba, et al.
Publicado: (2023)

Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients
por: Razi, Farideh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_65k391ukrsb7c4063e5evoj4n0