Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation

A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. Using a forward genetic screen, we have found a mutation in Tvp23b, which conferred susceptibility to...

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Detalles Bibliográficos
Autores principales: Song, Ran, McAlpine, William, Fond, Aaron M., Nair-Gill, Evan, Choi, Jin Huk, Nyström, Elisabeth E. L., Arike, Liisa, Field, Sydney, Li, Xiaohong, SoRelle, Jeffrey A., Moresco, James J., Moresco, Eva Marie Y., Yates, John R., Azadi, Parastoo, Ni, Josephine, Birchenough, George M. H., Beutler, Bruce, Turer, Emre E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282085/
https://www.ncbi.nlm.nih.gov/pubmed/37339972
http://dx.doi.org/10.1038/s41467-023-39398-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282085/
https://www.ncbi.nlm.nih.gov/pubmed/37339972
http://dx.doi.org/10.1038/s41467-023-39398-1

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