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Higher-order G-quadruplexes in promoters are untapped drug targets
G-quadruplexes (G4s) are four-stranded nucleic acid secondary structures that form within guanine-rich regions of chromatin. G4 motifs are abundant in the genome, with a sizable proportion (∼40%) existing within gene promoter regions. G4s are proven epigenetic features that decorate the promoter lan...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282141/ https://www.ncbi.nlm.nih.gov/pubmed/37351517 http://dx.doi.org/10.3389/fchem.2023.1211512 |