Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease

INTRODUCTION: Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington’s disease (HD). Excitatory amino acid transporter 2 (EAAT2), the predominant glutamate transporter accounting for >90% of glutamate transport, plays a k...

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Detalles Bibliográficos
Autores principales: Bhatnagar, Akanksha, Parmar, Visha, Barbieri, Nicholas, Bearoff, Frank, Elefant, Felice, Kortagere, Sandhya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282606/
https://www.ncbi.nlm.nih.gov/pubmed/37351153
http://dx.doi.org/10.3389/fnbeh.2023.1176777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282606/
https://www.ncbi.nlm.nih.gov/pubmed/37351153
http://dx.doi.org/10.3389/fnbeh.2023.1176777

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