Complement Activation by Adeno-Associated Virus-Neutralizing Antibody Complexes

Treatment of monogenetic disorders using vectors based on adeno-associated virus (AAV) is an area of intense interest. AAV is non-pathogenic human virus, and preexisting capsid antibodies are prevalent in the population posing a challenge to the safety and efficacy of AAV-mediated gene therapies. In...

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Detalles Bibliográficos
Autores principales: West, Cara, Federspiel, Joel D., Rogers, Kara, Khatri, Arpana, Rao-Dayton, Sheila, Ocana, Mireia Fernandez, Lim, Sean, D'Antona, Aaron Michael, Casinghino, Sandra, Somanathan, Suryanarayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282828/
https://www.ncbi.nlm.nih.gov/pubmed/37082966
http://dx.doi.org/10.1089/hum.2023.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282828/
https://www.ncbi.nlm.nih.gov/pubmed/37082966
http://dx.doi.org/10.1089/hum.2023.018

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