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Complement Activation by Adeno-Associated Virus-Neutralizing Antibody Complexes

Treatment of monogenetic disorders using vectors based on adeno-associated virus (AAV) is an area of intense interest. AAV is non-pathogenic human virus, and preexisting capsid antibodies are prevalent in the population posing a challenge to the safety and efficacy of AAV-mediated gene therapies. In...

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Detalles Bibliográficos
Autores principales:	West, Cara, Federspiel, Joel D., Rogers, Kara, Khatri, Arpana, Rao-Dayton, Sheila, Ocana, Mireia Fernandez, Lim, Sean, D'Antona, Aaron Michael, Casinghino, Sandra, Somanathan, Suryanarayan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282828/ https://www.ncbi.nlm.nih.gov/pubmed/37082966 http://dx.doi.org/10.1089/hum.2023.018

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