Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants.

Clinical variants of TARDBP are associated with frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and other degenerative diseases. The predicted C. elegans ortholog of TARDBP is encoded by tdp-1 , but functional orthology has not been demonstrated in vivo. We undertook CRISPR/Cas9-b...

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Detalles Bibliográficos
Autores principales: Lins, Jeremy, Brock, Trisha J, Hopkins, Chris E, Hart, Anne C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282831/
https://www.ncbi.nlm.nih.gov/pubmed/37351305
http://dx.doi.org/10.17912/micropub.biology.000693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282831/
https://www.ncbi.nlm.nih.gov/pubmed/37351305
http://dx.doi.org/10.17912/micropub.biology.000693

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