Cellular photo(geno)toxicity of gefitinib after biotransformation

Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads to chemically reactive metabolites such as O-Demethyl gefitinib (DMT-GFT), 4-Defluo...

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Detalles Bibliográficos
Autores principales: El Ouardi, Meryem, Tamarit, Lorena, Vayá, Ignacio, Miranda, Miguel A., Andreu, Inmaculada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283009/
https://www.ncbi.nlm.nih.gov/pubmed/37351506
http://dx.doi.org/10.3389/fphar.2023.1208075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283009/
https://www.ncbi.nlm.nih.gov/pubmed/37351506
http://dx.doi.org/10.3389/fphar.2023.1208075

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