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Computational Prediction of Metabolic α-Carbon Hydroxylation Potential of N-Nitrosamines: Overcoming Data Limitations for Carcinogenicity Assessment

[Image: see text] Recent withdrawal of several drugs from the market due to elevated levels of N-nitrosamine impurities underscores the need for computational approaches to assess the carcinogenicity risk of nitrosamines. However, current approaches are limited because robust animal carcinogenicity...

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Detalles Bibliográficos
Autor principal: Chakravarti, Suman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283024/
https://www.ncbi.nlm.nih.gov/pubmed/37267457
http://dx.doi.org/10.1021/acs.chemrestox.3c00083