Cargando…

Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix in the pulmonary interstitium and progressive functional decline. We hypothesized that integration of multi-omics data would identify clinically meaningful molecular endotypes of IPF. METHODS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruan, Peifeng, Todd, Jamie L, Zhao, Hongyu, Liu, Yi, Vinisko, Richard, Soellner, Julia F., Schmid, Ramona, Kaner, Robert J., Luckhardt, Tracy R., Neely, Megan L., Noth, Imre, Porteous, Mary, Raj, Rishi, Safdar, Zeenat, Strek, Mary E, Hesslinger, Christian, Palmer, Scott M., Leonard, Thomas B., Salisbury, Margaret L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283254/ https://www.ncbi.nlm.nih.gov/pubmed/37344825 http://dx.doi.org/10.1186/s12931-023-02435-0

Ejemplares similares

Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry
por: Todd, Jamie L., et al.
Publicado: (2019)

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort
por: Todd, Jamie L., et al.
Publicado: (2020)

From spirometry to spatial omics in pursuit of asthma endotypes
por: Hinks, Timothy S. C.
Publicado: (2022)

Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression
por: Garduno, Alexis, et al.
Publicado: (2023)

Expert consensus on the management of adverse events and prescribing practices associated with the treatment of patients taking pirfenidone for idiopathic pulmonary fibrosis: a Delphi consensus study
por: Rahaghi, Franck F., et al.
Publicado: (2020)

Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis
por: Kraven, Luke M, et al.
Publicado: (2023)

Reply to Lescoat et al. and to Khamis et al.
por: Adegunsoye, Ayodeji, et al.
Publicado: (2019)

Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma
por: Raita, Yoshihiko, et al.
Publicado: (2021)

Association of antinuclear antibody seropositivity with inhaled environmental exposures in patients with interstitial lung disease
por: Biblowitz, Kathleen, et al.
Publicado: (2021)

Merged Affinity Network Association Clustering: Joint multi-omic/clinical clustering to identify disease endotypes
por: Tyler, Scott R., et al.
Publicado: (2021)

Rhinitis Subtypes, Endotypes, and Definitions
por: Papadopoulos, Nikolaos G., et al.
Publicado: (2016)

Defining an embryonal rhabdomyosarcoma endotype
por: Ricker, Cora A., et al.
Publicado: (2020)

Clinical and Radiological Phenotypes and Endotypes
por: José, Ricardo J., et al.
Publicado: (2021)

Sepsis Endotypes Defined By Cytokine Trajectory Analysis
por: Zhu, L, et al.
Publicado: (2015)

Identification of Endotypes of Hospitalized COVID-19 Patients
por: Ranard, Benjamin L., et al.
Publicado: (2021)

Lung function trajectories in patients with idiopathic pulmonary fibrosis
por: Neely, Megan L, et al.
Publicado: (2023)

Molecular endotypes of type 1 and type 2 SLE
por: Robl, Robert, et al.
Publicado: (2023)

Skewed Lung CCR4 to CCR6 CD4(+) T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function
por: Adegunsoye, Ayodeji, et al.
Publicado: (2016)

T cell Co-Stimulatory molecules ICOS and CD28 stratify idiopathic pulmonary fibrosis survival
por: Bonham, Catherine A., et al.
Publicado: (2019)

Phenotypes and endotypes of severe asthma in children
por: Yoo, Young
Publicado: (2013)

Asthma Endotyping and Biomarkers in Childhood Asthma
por: Licari, Amelia, et al.
Publicado: (2018)

Endotyping Asthma: Profiling the Metabolic Dimension?
por: Wilde, Michael J., et al.
Publicado: (2021)

Neutrophil to lymphocyte ratio is a better indicator of COPD exacerbation severity in neutrophilic endotypes than eosinophilic endotypes
por: Aksoy, Emine, et al.
Publicado: (2018)

Autoimmune Hypothyroidism As a Predictor of Mortality in Chronic Hypersensitivity Pneumonitis
por: Adegunsoye, Ayodeji, et al.
Publicado: (2017)

Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
por: Todd, Jamie L., et al.
Publicado: (2022)

Correction to: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
por: Todd, Jamie L., et al.
Publicado: (2022)

Asthma Endotypes and an Overview of Targeted Therapy for Asthma
por: Svenningsen, Sarah, et al.
Publicado: (2017)

Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities
por: Koennecke, Michael, et al.
Publicado: (2018)

Inflammatory Endotypes and Microbial Associations in Chronic Rhinosinusitis
por: Hoggard, Michael, et al.
Publicado: (2018)

Recent advances in understanding chronic rhinosinusitis endotypes
por: Succar, Eric F., et al.
Publicado: (2018)

Arginine metabolic endotypes related to asthma severity
por: Xu, Weiling, et al.
Publicado: (2017)

Composed endotypes to guide antibiotic discontinuation in sepsis
por: Bermejo-Martin, Jesus F., et al.
Publicado: (2019)

Cytokine Patterns and Endotypes in Acute and Chronic Rhinosinusitis
por: Scheckenbach, Kathrin, et al.
Publicado: (2015)

Defining Pediatric Asthma: Phenotypes to Endotypes and Beyond
por: Conrad, Laura A., et al.
Publicado: (2020)

Phenotypes and Endotypes of Peach Allergy: What Is New?
por: Barni, Simona, et al.
Publicado: (2022)

Novel Biological Therapies for Severe Asthma Endotypes
por: Pelaia, Corrado, et al.
Publicado: (2022)

Discerning asthma endotypes through comorbidity mapping
por: Jia, Gengjie, et al.
Publicado: (2022)

Editorial: Endotyping and phenotyping prematurity and its complications
por: Pierro, Maria, et al.
Publicado: (2023)

Immunological Endotyping of Chronic Critical Illness After Severe Sepsis
por: Fenner, Brittany P., et al.
Publicado: (2021)

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype
por: Fricker, Michael, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bb7gho75hstnqq3m85gh0vb785