Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

The TP53 and PTEN tumour suppressor genes are inactivated by nonsense mutations in a significant fraction of human tumours. TP53 nonsense mutatant tumours account for approximately one million new cancer cases per year worldwide. We have screened chemical libraries with the aim of identifying compou...

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Detalles Bibliográficos
Autores principales: Heldin, Angelos, Cancer, Matko, Palomar-Siles, Mireia, Öhlin, Susanne, Zhang, Meiqiongzi, Sun-Zhang, Alexander, Mariani, Anna, Liu, Jianping, Bykov, Vladimir J.N., Wiman, Klas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283442/
https://www.ncbi.nlm.nih.gov/pubmed/37339263
http://dx.doi.org/10.1080/15476286.2023.2222250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283442/
https://www.ncbi.nlm.nih.gov/pubmed/37339263
http://dx.doi.org/10.1080/15476286.2023.2222250

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