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Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection

BACKGROUND: Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve understanding of its causes and identify new molecular targets f...

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Detalles Bibliográficos
Autores principales: Packer, Richard J., Shrine, Nick, Hall, Robert, Melbourne, Carl A., Thompson, Rebecca, Williams, Alex T., Paynton, Megan L., Guyatt, Anna L., Allen, Richard J., Lee, Paul H., John, Catherine, Campbell, Archie, Hayward, Caroline, de Vries, Maaike, Vonk, Judith M., Davitte, Jonathan, Hessel, Edith, Michalovich, David, Betts, Joanna C., Sayers, Ian, Yeo, Astrid, Hall, Ian P., Tobin, Martin D., Wain, Louise V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284065/
https://www.ncbi.nlm.nih.gov/pubmed/37263751
http://dx.doi.org/10.1183/13993003.01667-2022