Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response

The modestly efficacious HIV-1 vaccine regimen (RV144) conferred 31% vaccine efficacy at 3 years following the four-shot immunization series, coupled with rapid waning of putative immune correlates of decreased infection risk. New strategies to increase magnitude and durability of protective immunit...

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Detalles Bibliográficos
Autores principales: Williams, LaTonya D., Shen, Xiaoying, Sawant, Sheetal S., Akapirat, Siriwat, Dahora, Lindsay C., Tay, Matthew Zirui, Stanfield-Oakley, Sherry, Wills, Saintedym, Goodman, Derrick, Tenney, DeAnna, Spreng, Rachel L., Zhang, Lu, Yates, Nicole L., Montefiori, David C., Eller, Michael A., Easterhoff, David, Hope, Thomas J., Rerks-Ngarm, Supachai, Pittisuttithum, Punnee, Nitayaphan, Sorachai, Excler, Jean-Louis, Kim, Jerome H., Michael, Nelson L., Robb, Merlin L., O’Connell, Robert J., Karasavvas, Nicos, Vasan, Sandhya, Ferrari, Guido, Tomaras, Georgia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284421/
https://www.ncbi.nlm.nih.gov/pubmed/37256916
http://dx.doi.org/10.1371/journal.ppat.1011359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284421/
https://www.ncbi.nlm.nih.gov/pubmed/37256916
http://dx.doi.org/10.1371/journal.ppat.1011359

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