A cytosolic surveillance mechanism activates the mitochondrial UPR

The mitochondrial unfolded protein response (UPR(mt)) is essential to safeguard mitochondria from proteotoxic damage by activating a dedicated transcriptional response in the nucleus to restore proteostasis(1,2). Yet, it remains unclear how the information on mitochondria misfolding stress (MMS) is...

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Detalles Bibliográficos
Autores principales: Sutandy, F. X. Reymond, Gößner, Ines, Tascher, Georg, Münch, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284689/
https://www.ncbi.nlm.nih.gov/pubmed/37286597
http://dx.doi.org/10.1038/s41586-023-06142-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284689/
https://www.ncbi.nlm.nih.gov/pubmed/37286597
http://dx.doi.org/10.1038/s41586-023-06142-0

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