Engineered tRNAs suppress nonsense mutations in cells and in vivo

Nonsense mutations are the underlying cause of approximately 11% of all inherited genetic diseases(1). Nonsense mutations convert a sense codon that is decoded by tRNA into a premature termination codon (PTC), resulting in an abrupt termination of translation. One strategy to suppress nonsense mutat...

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Detalles Bibliográficos
Autores principales: Albers, Suki, Allen, Elizabeth C., Bharti, Nikhil, Davyt, Marcos, Joshi, Disha, Perez-Garcia, Carlos G., Santos, Leonardo, Mukthavaram, Rajesh, Delgado-Toscano, Miguel Angel, Molina, Brandon, Kuakini, Kristen, Alayyoubi, Maher, Park, Kyoung-Joo Jenny, Acharya, Grishma, Gonzalez, Jose A., Sagi, Amit, Birket, Susan E., Tearney, Guillermo J., Rowe, Steven M., Manfredi, Candela, Hong, Jeong S., Tachikawa, Kiyoshi, Karmali, Priya, Matsuda, Daiki, Sorscher, Eric J., Chivukula, Pad, Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284701/
https://www.ncbi.nlm.nih.gov/pubmed/37258671
http://dx.doi.org/10.1038/s41586-023-06133-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284701/
https://www.ncbi.nlm.nih.gov/pubmed/37258671
http://dx.doi.org/10.1038/s41586-023-06133-1

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