Polygenic scoring accuracy varies across the genetic ancestry continuum

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use(1–3). PGS portability has typically been assessed using a single aggregate population-level statistic (...

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Detalles Bibliográficos
Autores principales: Ding, Yi, Hou, Kangcheng, Xu, Ziqi, Pimplaskar, Aditya, Petter, Ella, Boulier, Kristin, Privé, Florian, Vilhjálmsson, Bjarni J., Olde Loohuis, Loes M., Pasaniuc, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284707/
https://www.ncbi.nlm.nih.gov/pubmed/37198491
http://dx.doi.org/10.1038/s41586-023-06079-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284707/
https://www.ncbi.nlm.nih.gov/pubmed/37198491
http://dx.doi.org/10.1038/s41586-023-06079-4

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