The effect of blocking immune checkpoints LAG-3 and PD-1 on human invariant Natural Killer T cell function

Invariant Natural Killer T (iNKT) cells undergo immune exhaustion during chronic activation caused by cancer and viral infections, such as HIV. Exhaustion is marked by cell dysfunction and increased expression of immune checkpoint proteins programmed cell-death-1 (PD-1) and lymphocyte-activation-gen...

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Detalles Bibliográficos
Autores principales: Balasko, Allison L., Kowatsch, Monika M., Graydon, Colin, Lajoie, Julie, Fowke, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284876/
https://www.ncbi.nlm.nih.gov/pubmed/37344517
http://dx.doi.org/10.1038/s41598-023-36468-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284876/
https://www.ncbi.nlm.nih.gov/pubmed/37344517
http://dx.doi.org/10.1038/s41598-023-36468-8

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