Cargando…

Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage

NLRP3 is an important innate immune sensor that responses to various signals and forms the inflammasome complex, leading to IL-1β secretion and pyroptosis. Lysosomal damage has been implicated in NLRP3 inflammasome activation in response to crystals or particulates, but the mechanism remains unclear...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Yingting, He, Hongbin, Ma, Ming, Zhou, Rongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285205/
https://www.ncbi.nlm.nih.gov/pubmed/37359517
http://dx.doi.org/10.3389/fimmu.2023.1128700