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Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage
NLRP3 is an important innate immune sensor that responses to various signals and forms the inflammasome complex, leading to IL-1β secretion and pyroptosis. Lysosomal damage has been implicated in NLRP3 inflammasome activation in response to crystals or particulates, but the mechanism remains unclear...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285205/ https://www.ncbi.nlm.nih.gov/pubmed/37359517 http://dx.doi.org/10.3389/fimmu.2023.1128700 |