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Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage

NLRP3 is an important innate immune sensor that responses to various signals and forms the inflammasome complex, leading to IL-1β secretion and pyroptosis. Lysosomal damage has been implicated in NLRP3 inflammasome activation in response to crystals or particulates, but the mechanism remains unclear...

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Detalles Bibliográficos
Autores principales:	Hou, Yingting, He, Hongbin, Ma, Ming, Zhou, Rongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285205/ https://www.ncbi.nlm.nih.gov/pubmed/37359517 http://dx.doi.org/10.3389/fimmu.2023.1128700

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