Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier

The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in particular incomplete binding was observed in a mi...

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Detalles Bibliográficos
Autores principales: Tekwani Movellan, Kumar, Wegstroth, Melanie, Overkamp, Kerstin, Leonov, Andrei, Becker, Stefan, Andreas, Loren B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285276/
https://www.ncbi.nlm.nih.gov/pubmed/37363040
http://dx.doi.org/10.1016/j.yjsbx.2023.100090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285276/
https://www.ncbi.nlm.nih.gov/pubmed/37363040
http://dx.doi.org/10.1016/j.yjsbx.2023.100090

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