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Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in particular incomplete binding was observed in a mi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285276/ https://www.ncbi.nlm.nih.gov/pubmed/37363040 http://dx.doi.org/10.1016/j.yjsbx.2023.100090 |