HDAC1 regulates the chromatin landscape to control transcriptional dependencies in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a quiescent B-cell malignancy that depends on transcriptional dysregulation for survival. The histone deacetylases are transcriptional regulators whose role within the regulatory chromatin and consequence on the CLL transcriptome is poorly characterized. Here, w...

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Detalles Bibliográficos
Autores principales: Lai, Tzung-Huei, Ozer, Hatice Gulcin, Gasparini, Pierluigi, Nigita, Giovanni, Distefano, Rosario, Yu, Lianbo, Ravikrishnan, Janani, Yilmaz, Selen, Gallegos, Juan, Shukla, Sachet, Puduvalli, Vinay, Woyach, Jennifer, Lapalombella, Rosa, Blachly, James, Byrd, John C., Sampath, Deepa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285551/
https://www.ncbi.nlm.nih.gov/pubmed/36287107
http://dx.doi.org/10.1182/bloodadvances.2022007998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285551/
https://www.ncbi.nlm.nih.gov/pubmed/36287107
http://dx.doi.org/10.1182/bloodadvances.2022007998

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