Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across

The liver is the most common target organ in toxicology studies. The development of chemical structural alerts for identifying hepatotoxicity will play an important role in in silico model prediction and help strengthen the identification of analogs used in structure activity relationship (SAR)- bas...

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Detalles Bibliográficos
Autores principales: Wu, Shengde, Daston, George, Rose, Jane, Blackburn, Karen, Fisher, Joan, Reis, Allison, Selman, Bastian, Naciff, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285556/
https://www.ncbi.nlm.nih.gov/pubmed/37363741
http://dx.doi.org/10.1016/j.crtox.2023.100108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285556/
https://www.ncbi.nlm.nih.gov/pubmed/37363741
http://dx.doi.org/10.1016/j.crtox.2023.100108

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