Master regulator activity QTL protocol to implicate regulatory pathways potentially mediating GWAS signals using eQTL data

Here, we present a protocol to identify transcriptional regulators potentially mediating downstream biological effects of germline variants associated with complex traits of interest, which enables functional hypothesis generation independent of colocalizing expression quantitative trait loci (eQTLs...

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Detalles Bibliográficos
Autores principales: Hoskins, Jason W., Christensen, Trevor A., Amundadottir, Laufey T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285694/
https://www.ncbi.nlm.nih.gov/pubmed/37330907
http://dx.doi.org/10.1016/j.xpro.2023.102362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285694/
https://www.ncbi.nlm.nih.gov/pubmed/37330907
http://dx.doi.org/10.1016/j.xpro.2023.102362

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