Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity

BACKGROUND: Low back pain is a major contributor to disability worldwide and generates a tremendous socioeconomic impact. The degenerative intervertebral disc (IVD) has been hypothesized to contribute to discogenic pain by sensitizing nociceptive neurons innervating the disc to stimuli that is nonpa...

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Detalles Bibliográficos
Autores principales: Stover, Joshua D., Trone, Matthew A., Lawrence, Brandon, Bowles, Robby D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285767/
https://www.ncbi.nlm.nih.gov/pubmed/37361323
http://dx.doi.org/10.1002/jsp2.1253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285767/
https://www.ncbi.nlm.nih.gov/pubmed/37361323
http://dx.doi.org/10.1002/jsp2.1253

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