Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT(1A) and 5-HT(7A) Receptors

[Image: see text] We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-2,3-dihydro-1H-inden-1-one (SYA0340) as a dual 5-HT(1A) and 5-HT(7) receptor ligand, and we posited such ligands might find utility in the treatment of various CNS related illnesses includi...

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Detalles Bibliográficos
Autores principales: Bricker, Barbara A., Voshavar, Chandrashekhar, Onyameh, Edem K., Gonela, Uma M., Lin, Xinsong, Swanson, Tracy L., Kozell, Laura B., Schmachtenberg, Jennifer L., Bloom, Shelley H., Janowsky, Aaron J., Ablordeppey, Seth Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285950/
https://www.ncbi.nlm.nih.gov/pubmed/37360419
http://dx.doi.org/10.1021/acsomega.3c01283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285950/
https://www.ncbi.nlm.nih.gov/pubmed/37360419
http://dx.doi.org/10.1021/acsomega.3c01283

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