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Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT(1A) and 5-HT(7A) Receptors
[Image: see text] We have previously identified 5-chloro-2-methyl-2-(3-(4-(pyridin-2-yl)piperazin-1-yl)propyl)-2,3-dihydro-1H-inden-1-one (SYA0340) as a dual 5-HT(1A) and 5-HT(7) receptor ligand, and we posited such ligands might find utility in the treatment of various CNS related illnesses includi...
Autores principales: | Bricker, Barbara A., Voshavar, Chandrashekhar, Onyameh, Edem K., Gonela, Uma M., Lin, Xinsong, Swanson, Tracy L., Kozell, Laura B., Schmachtenberg, Jennifer L., Bloom, Shelley H., Janowsky, Aaron J., Ablordeppey, Seth Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285950/ https://www.ncbi.nlm.nih.gov/pubmed/37360419 http://dx.doi.org/10.1021/acsomega.3c01283 |
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