Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

[Image: see text] The aberrant misfolding and aggregation of peptides and proteins into amyloid aggregates occurs in over 50 largely incurable protein misfolding diseases. These pathologies include Alzheimer’s and Parkinson’s diseases, which are global medical emergencies owing to their prevalence i...

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Detalles Bibliográficos
Autores principales: Limbocker, Ryan, Cremades, Nunilo, Cascella, Roberta, Tessier, Peter M., Vendruscolo, Michele, Chiti, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286310/
https://www.ncbi.nlm.nih.gov/pubmed/37071750
http://dx.doi.org/10.1021/acs.accounts.3c00045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286310/
https://www.ncbi.nlm.nih.gov/pubmed/37071750
http://dx.doi.org/10.1021/acs.accounts.3c00045

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