Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

BACKGROUND: Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Chemotherapy-induced peripheral neuropathy (CIPN)...

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Detalles Bibliográficos
Autores principales: Khan, Zia, Jung, Min, Crow, Megan, Mohindra, Rajat, Maiya, Vidya, Kaminker, Joshua S., Hackos, David H., Chandler, G. Scott, McCarthy, Mark I., Bhangale, Tushar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286344/
https://www.ncbi.nlm.nih.gov/pubmed/37344884
http://dx.doi.org/10.1186/s13073-023-01193-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286344/
https://www.ncbi.nlm.nih.gov/pubmed/37344884
http://dx.doi.org/10.1186/s13073-023-01193-4

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