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MiR-137 promotes TLR4/NF-κB pathway activity through targeting KDM4A, inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells and aggravates osteoporosis

PURPOSE: As the global population ages rapidly, osteoporotic fractures have become an important public health problem. Previous studies have suggested that miR-137 is involved in the regulation of bone formation, but its specific regulatory mechanism remains unclear. In this study, we aimed to explo...

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Detalles Bibliográficos
Autores principales: Yu, Ying-feng, Yao, Pei-quan, Wang, Zhi-kun, Xie, Wen-wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286393/
https://www.ncbi.nlm.nih.gov/pubmed/37344864
http://dx.doi.org/10.1186/s13018-023-03918-y