DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of Alzheimer’s disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) controls cellular cholesterol homeostasis, which was found to be downregulated in AD vulnerable regions and involved in...

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Detalles Bibliográficos
Autores principales: Zhang, Wen-bin, Huang, Yue, Guo, Xiao-rou, Zhang, Meng-qi, Yuan, Xiang-shan, Zu, Heng-bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286507/
https://www.ncbi.nlm.nih.gov/pubmed/37344916
http://dx.doi.org/10.1186/s40478-023-01593-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286507/
https://www.ncbi.nlm.nih.gov/pubmed/37344916
http://dx.doi.org/10.1186/s40478-023-01593-y

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