Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening, docking, and ADME studies

Novel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line with IC(50) of 0.5–190nM. Compounds 8c and 9g showed preferential activity against Hela cells (IC(50): 1.69 and 1.52 μM respectively). Howeve...

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Detalles Bibliográficos
Autores principales: Bedewy, Walaa A., Mohamed, Mosaad S., Abdelhameed, Ahmed M., Elsawy, Mohamed A., Al-Muhur, Mohammed, Ashida, Noriyuki, Abdalla, Ashraf N, Elwaie, Tamer A., Nagamatsu, Tomohisa, Ali, Hamed I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286681/
https://www.ncbi.nlm.nih.gov/pubmed/37341389
http://dx.doi.org/10.1080/14756366.2023.2220570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286681/
https://www.ncbi.nlm.nih.gov/pubmed/37341389
http://dx.doi.org/10.1080/14756366.2023.2220570

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