7H‐Pyrrolo[2,3‐d]pyrimidine‐4‐amines as Potential Inhibitors of Plasmodium falciparum Calcium‐Dependent Protein Kinases

A series of pyrrolo[2,3‐d]pyrimidines were designed in silico as potential bumped kinase inhibitors targeting P. falciparum calcium dependent protein kinase 4 (PfCDPK4), with the potential to inhibit PfCDPK1 based on earlier studies of the two kinases. A small series of these compounds were prepared...

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Detalles Bibliográficos
Autores principales: Seanego, Tswene D., Chavalala, Hlamulo E., Henning, Hendrik H., de Koning, Charles B., Hoppe, Heinrich C., Ojo, Kayode K., Rousseau, Amanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286757/
https://www.ncbi.nlm.nih.gov/pubmed/36106757
http://dx.doi.org/10.1002/cmdc.202200421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286757/
https://www.ncbi.nlm.nih.gov/pubmed/36106757
http://dx.doi.org/10.1002/cmdc.202200421

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