A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies

Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that combine multiple antibody-binding domains to induce active contact between T-cells and antigen expressing cells in the body. Blinatumomab, a CD19-CD3 BiTE is now a widely used therapy for relapsed B-cell malignancies,...

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Detalles Bibliográficos
Autores principales: Shepherd, Alex, Bennychen, Bigitha, Marcil, Anne, Bloemberg, Darin, Pon, Robert A., Weeratna, Risini D., McComb, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286961/
https://www.ncbi.nlm.nih.gov/pubmed/37347762
http://dx.doi.org/10.1371/journal.pone.0273884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286961/
https://www.ncbi.nlm.nih.gov/pubmed/37347762
http://dx.doi.org/10.1371/journal.pone.0273884

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