Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

Ribosomal protein (Rp) gene haploinsufficiency can result in Diamond-Blackfan Anemia (DBA), characterized by defective erythropoiesis and skeletal defects. Some mouse Rp mutations recapitulate DBA phenotypes, although others lack erythropoietic or skeletal defects. We generated a conditional knockou...

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Detalles Bibliográficos
Autores principales: Folgado-Marco, Virginia, Ames, Kristina, Chuen, Jacky, Gritsman, Kira, Baker, Nicholas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287158/
https://www.ncbi.nlm.nih.gov/pubmed/37272618
http://dx.doi.org/10.7554/eLife.69322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287158/
https://www.ncbi.nlm.nih.gov/pubmed/37272618
http://dx.doi.org/10.7554/eLife.69322

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