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Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance

Ribosomal protein (Rp) gene haploinsufficiency can result in Diamond-Blackfan Anemia (DBA), characterized by defective erythropoiesis and skeletal defects. Some mouse Rp mutations recapitulate DBA phenotypes, although others lack erythropoietic or skeletal defects. We generated a conditional knockou...

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Detalles Bibliográficos
Autores principales:	Folgado-Marco, Virginia, Ames, Kristina, Chuen, Jacky, Gritsman, Kira, Baker, Nicholas E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287158/ https://www.ncbi.nlm.nih.gov/pubmed/37272618 http://dx.doi.org/10.7554/eLife.69322

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