Cargando…

Increased plasma level of terminal complement complex in AMD patients: potential functional consequences for RPE cells

PURPOSE: Polymorphisms in complement genes are risk-associated for age-related macular degeneration (AMD). Functional analysis revealed a common deficiency to control the alternative complement pathway by risk-associated gene polymorphisms. Thus, we investigated the levels of terminal complement com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Busch, Catharina, Rau, Saskia, Sekulic, Andjela, Perie, Luce, Huber, Christian, Gehrke, Miranda, Joussen, Antonia M., Zipfel, Peter F., Wildner, Gerhild, Skerka, Christine, Strauß, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287163/ https://www.ncbi.nlm.nih.gov/pubmed/37359546 http://dx.doi.org/10.3389/fimmu.2023.1200725

Ejemplares similares

Anaphylatoxins Activate Ca(2+), Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium
por: Busch, Catharina, et al.
Publicado: (2017)

Early OCT Angiography Changes of Macular Neovascularization in Patients with Exudative AMD Treated with Brolucizumab in a Real-World Setting
por: Rübsam, Anne, et al.
Publicado: (2022)

Role of Resveratrol in Transmitochondrial AMD RPE Cells
por: Nashine, Sonali, et al.
Publicado: (2020)

Fluorescence Lifetimes and Spectra of RPE and Sub-RPE Deposits in Histology of Control and AMD Eyes
por: Schultz, Rowena, et al.
Publicado: (2020)

Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE
por: Fisher, Cody R., et al.
Publicado: (2018)

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis
por: Gao, Jiangyuan, et al.
Publicado: (2019)

Complement catalyzing glomerular diseases
por: Zipfel, Peter F., et al.
Publicado: (2021)

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7
por: Zhang, Youwen, et al.
Publicado: (2017)

Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE
por: Peters, Florian, et al.
Publicado: (2022)

RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models
por: Millington-Ward, Sophia, et al.
Publicado: (2023)

Impact of intravitreal injection therapy on contrast sensitivity in patients with nAMD and DME
por: Dieke, Sebastian, et al.
Publicado: (2023)

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
por: Diedrichs-Möhring, Maria, et al.
Publicado: (2018)

Complement Inhibitors in Clinical Trials for Glomerular Diseases
por: Zipfel, Peter F., et al.
Publicado: (2019)

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
por: Jiang, Mei, et al.
Publicado: (2015)

Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance of Borrelia burgdorferi
por: Hammerschmidt, Claudia, et al.
Publicado: (2012)

Scribble basal polarity acquisition in RPE cells and its mislocalization in a pathological AMD-like model
por: Segurado, Alicia, et al.
Publicado: (2022)

AMD and the alternative complement pathway: genetics and functional implications
por: Tan, Perciliz L., et al.
Publicado: (2016)

Complement Activation Levels Are Related to Disease Stage in AMD
por: Heesterbeek, Thomas J., et al.
Publicado: (2020)

CspA from Borrelia burgdorferi Inhibits the Terminal Complement Pathway
por: Hallström, Teresia, et al.
Publicado: (2013)

Borrelia valaisiana Resist Complement-Mediated Killing Independently of the Recruitment of Immune Regulators and Inactivation of Complement Components
por: Schwab, Jasmin, et al.
Publicado: (2013)

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator
por: Micklisch, Sven, et al.
Publicado: (2017)

PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics
por: Nashine, Sonali, et al.
Publicado: (2019)

Oligomeric Aβ(1-42) Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function
por: Lynn, Savannah A., et al.
Publicado: (2021)

DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features
por: Ma, Xiaoyin, et al.
Publicado: (2023)

Co-cultivation of primary porcine RPE cells and neuroretina induces inflammation: a potential inflammatory AMD-model
por: Fietz, Agnes, et al.
Publicado: (2023)

Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: A novel culture model for dry AMD
por: Rabin, David M., et al.
Publicado: (2012)

Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids
por: Nashine, Sonali, et al.
Publicado: (2016)

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells
por: Schäfer, Nicole, et al.
Publicado: (2021)

MOBILIZATION STUDIES IN COMPLEMENT-DEFICIENT MICE REVEAL THAT OPTIMAL AMD3100 MOBILIZATION OF HEMATOPOIETIC STEM CELLS DEPENDS ON COMPLEMENT CASCADE ACTIVATION BY AMD3100-STIMULATED GRANULOCYTES
por: Lee, HakMo, et al.
Publicado: (2009)

The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b
por: Haupt, Katrin, et al.
Publicado: (2008)

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells
por: Yang, Ping, et al.
Publicado: (2017)

Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B
por: Pilotti, Camilla, et al.
Publicado: (2020)

A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for In Vitro Studies in AMD
por: Shang, Peng, et al.
Publicado: (2021)

Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack
por: Hallström, Teresia, et al.
Publicado: (2015)

Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy
por: Gehrke, Miranda, et al.
Publicado: (2022)

AICAR suppresses TNF-α-induced complement factor B in RPE cells
por: Chung, Eun Jee, et al.
Publicado: (2017)

Complement System in Pathogenesis of AMD: Dual Player in Degeneration and Protection of Retinal Tissue
por: Kawa, Milosz P., et al.
Publicado: (2014)

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
por: Armento, Angela, et al.
Publicado: (2021)

The Protease SplB of Staphylococcus aureus Targets Host Complement Components and Inhibits Complement-Mediated Bacterial Opsonophagocytosis
por: Dasari, Prasad, et al.
Publicado: (2022)

In situ Visualization of C3/C5 Convertases to Differentiate Complement Activation
por: Person, Fermin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d6g7umvt1nmg3evdp0jb0am5uj