Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The...

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Detalles Bibliográficos
Autores principales: Gervais, Adrian, Rovida, Francesca, Avanzini, Maria Antonietta, Croce, Stefania, Marchal, Astrid, Lin, Shih-Ching, Ferrari, Alessandro, Thorball, Christian W., Constant, Orianne, Le Voyer, Tom, Philippot, Quentin, Rosain, Jérémie, Angelini, Micol, Pérez Lorenzo, Malena, Bizien, Lucy, Achille, Cristian, Trespidi, Francesca, Burdino, Elisa, Cassaniti, Irene, Lilleri, Daniele, Fornara, Chiara, Sammartino, José Camilla, Cereda, Danilo, Marrocu, Chiara, Piralla, Antonio, Valsecchi, Chiara, Ricagno, Stefano, Cogo, Paola, Neth, Olaf, Marín-Cruz, Inés, Pacenti, Monia, Sinigaglia, Alessandro, Trevisan, Marta, Volpe, Andrea, Marzollo, Antonio, Conti, Francesca, Lazzarotto, Tiziana, Pession, Andrea, Viale, Pierluigi, Fellay, Jacques, Ghirardello, Stefano, Aubart, Mélodie, Ghisetti, Valeria, Aiuti, Alessandro, Jouanguy, Emmanuelle, Bastard, Paul, Percivalle, Elena, Baldanti, Fausto, Puel, Anne, MacDonald, Margaret R., Rice, Charles M., Rossini, Giada, Murray, Kristy O., Simonin, Yannick, Nagy, Anna, Barzon, Luisa, Abel, Laurent, Diamond, Michael S., Cobat, Aurélie, Zhang, Shen-Ying, Casanova, Jean-Laurent, Borghesi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287549/
https://www.ncbi.nlm.nih.gov/pubmed/37347462
http://dx.doi.org/10.1084/jem.20230661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287549/
https://www.ncbi.nlm.nih.gov/pubmed/37347462
http://dx.doi.org/10.1084/jem.20230661

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