[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies

Regarding the important role of the urease enzyme as a virulence factor in urease-positive microorganisms in this study, new series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. All compounds evaluated against urease enzyme exhibiting IC(50) values of 0.87 ± ...

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Detalles Bibliográficos
Autores principales: Khalili Ghomi, Minoo, Noori, Milad, Nazari Montazer, Mohammad, Zomorodian, Kamiar, Dastyafteh, Navid, Yazdanpanah, Somayeh, Sayahi, Mohammad Hosein, Javanshir, Shahrzad, Nouri, Abbas, Asadi, Mehdi, Badali, Hamid, Larijani, Bagher, Irajie, Cambyz, Iraji, Aida, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287669/
https://www.ncbi.nlm.nih.gov/pubmed/37349372
http://dx.doi.org/10.1038/s41598-023-37203-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287669/
https://www.ncbi.nlm.nih.gov/pubmed/37349372
http://dx.doi.org/10.1038/s41598-023-37203-z

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