A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors

Structure elucidation of inactive-state GPCRs still mostly relies on X-ray crystallography. The major goal of our work was to create a new GPCR tool that would provide receptor stability and additional soluble surface for crystallization. Towards this aim, we selected the two-stranded antiparallel c...

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Detalles Bibliográficos
Autores principales: Amer, Marwa, Leka, Oneda, Jasko, Piotr, Frey, Daniel, Li, Xiaodan, Kammerer, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287670/
https://www.ncbi.nlm.nih.gov/pubmed/37349348
http://dx.doi.org/10.1038/s41598-023-36855-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287670/
https://www.ncbi.nlm.nih.gov/pubmed/37349348
http://dx.doi.org/10.1038/s41598-023-36855-1

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