Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein

Viral RNA-host protein interactions are indispensable during RNA virus transcription and replication, but their detailed structural and dynamical features remain largely elusive. Here, we characterize the binding interface for the SARS-CoV-2 stem-loop 3 (SL3) cis-acting element to human TIA1 protein...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Qiao, Lulu, Lei, Xiaobo, Dong, Xiaojing, Tong, Yunguang, Wang, Jianwei, Wang, Zhiye, Zhou, Ruhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287707/
https://www.ncbi.nlm.nih.gov/pubmed/37349329
http://dx.doi.org/10.1038/s41467-023-39410-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287707/
https://www.ncbi.nlm.nih.gov/pubmed/37349329
http://dx.doi.org/10.1038/s41467-023-39410-8

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