5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid transporters, making it an ideal agent for BNCT...

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Detalles Bibliográficos
Autores principales: Fukumura, Masao, Nonoguchi, Naosuke, Kawabata, Shinji, Hiramatsu, Ryo, Futamura, Gen, Takeuchi, Koji, Kanemitsu, Takuya, Takata, Takushi, Tanaka, Hiroki, Suzuki, Minoru, Sampetrean, Oltea, Ikeda, Naokado, Kuroiwa, Toshihiko, Saya, Hideyuki, Nakano, Ichiro, Wanibuchi, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287723/
https://www.ncbi.nlm.nih.gov/pubmed/37349515
http://dx.doi.org/10.1038/s41598-023-37296-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287723/
https://www.ncbi.nlm.nih.gov/pubmed/37349515
http://dx.doi.org/10.1038/s41598-023-37296-6

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