Cargando…

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level. Here we show that mitochondrial aconitase, ACO-2, a Krebs cycle enzyme that catalyzes the con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Eunah, Annibal, Andrea, Lee, Yujin, Park, Hae-Eun H., Ham, Seokjin, Jeong, Dae-Eun, Kim, Younghun, Park, Sangsoon, Kwon, Sujeong, Jung, Yoonji, Park, JiSoo, Kim, Sieun S., Antebi, Adam, Lee, Seung-Jae V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287738/ https://www.ncbi.nlm.nih.gov/pubmed/37349299 http://dx.doi.org/10.1038/s41467-023-39393-6

Ejemplares similares

Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans
por: Ham, Seokjin, et al.
Publicado: (2022)

Age-dependent upregulation of Y RNAs in Caenorhabditis elegans
por: Park, Sangsoon, et al.
Publicado: (2021)

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
por: Park, Hae-Eun H., et al.
Publicado: (2021)

Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids
por: Jung, Yoonji, et al.
Publicado: (2020)

Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop
por: Lee, Yujin, et al.
Publicado: (2021)

Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO
por: Park, Sangsoon, et al.
Publicado: (2020)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
por: Ternette, Nicola, et al.
Publicado: (2013)

Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart
por: Stepanova, Anna, et al.
Publicado: (2016)

Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged flies
por: Cho, Yun‐Ho, et al.
Publicado: (2021)

Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
por: Singh, Keshav K, et al.
Publicado: (2006)

Mitochondrial DNA Instability in Cells Lacking Aconitase Correlates with Iron Citrate Toxicity
por: Farooq, Muhammad A., et al.
Publicado: (2013)

Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria
por: Jeong, Dae-Eun, et al.
Publicado: (2020)

RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
por: Park, Sangsoon, et al.
Publicado: (2017)

Fluorescent Materials for Monitoring Mitochondrial Biology
por: Chu, Yeonjeong, et al.
Publicado: (2021)

Nitric Oxide Improves the Tolerance of Pleurotus ostreatus to Heat Stress by Inhibiting Mitochondrial Aconitase
por: Hou, Ludan, et al.
Publicado: (2020)

GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress
por: Meng, Xiangxiang, et al.
Publicado: (2022)

Caenorhabditis elegans algn-2 Is Critical for Longevity Conferred by Enhanced Nonsense-Mediated mRNA Decay
por: Kim, Eun Ji E., et al.
Publicado: (2020)

Membrane potential‐dependent regulation of mitochondrial complex II by oxaloacetate in interscapular brown adipose tissue
por: Fink, Brian D., et al.
Publicado: (2021)

Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency
por: Abela, Lucia, et al.
Publicado: (2017)

ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response
por: Pascual, Jesús, et al.
Publicado: (2021)

Oxaloacetate acid ameliorates paraquat-induced acute lung injury by alleviating oxidative stress and mitochondrial dysfunction
por: Li, Wenwen, et al.
Publicado: (2022)

VRK-1 extends life span by activation of AMPK via phosphorylation
por: Park, Sangsoon, et al.
Publicado: (2020)

Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation
por: Xue, Ya‐Nan, et al.
Publicado: (2019)

Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling
por: You, Xin, et al.
Publicado: (2021)

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
por: Mirhadi, Shideh, et al.
Publicado: (2023)

Mitochondrial Aconitase Enzymatic Activity: A Potential Long-Term Survival Biomarker in the Blood of ALS Patients
por: González-Mingot, Cristina, et al.
Publicado: (2023)

Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue
por: Yu, Liping, et al.
Publicado: (2023)

AMPK-induced mitochondrial biogenesis decelerates retinal pigment epithelial cell degeneration under nutrient starvation
por: Park, Yujin, et al.
Publicado: (2023)

Strategies for accelerating osteogenesis through nanoparticle-based DNA/mitochondrial damage repair
por: Kim, Hye Jin, et al.
Publicado: (2022)

Effect of Salt Stress on the Expression and Promoter Methylation of the Genes Encoding the Mitochondrial and Cytosolic Forms of Aconitase and Fumarase in Maize
por: Eprintsev, Alexander T., et al.
Publicado: (2021)

Aconitase: To Be or not to Be Inside Plant Glyoxysomes, That Is the Question
por: De Bellis, Luigi, et al.
Publicado: (2020)

Preferred Migration of Mitochondria toward Cells and Tissues with Mitochondrial Damage
por: Lee, Seo-Eun, et al.
Publicado: (2022)

Enhanced cardiac fatty acid utilization induced by high dietary fat: a potential regulatory role for mitochondrial aconitase
por: Fernandes, Jolyn, et al.
Publicado: (2012)

Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily
por: Watanabe, Seiya, et al.
Publicado: (2021)

Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD
por: Yoon, Nam Soo, et al.
Publicado: (2010)

Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
por: Son, Heehwa G., et al.
Publicado: (2018)

The mitochondrial genome of the goosander (Mergus merganser) determined using next-generation sequencing
por: Lee, Seon-Mi, et al.
Publicado: (2019)

Mitochondrial Transplantation as a Novel Therapeutic Strategy for Mitochondrial Diseases
por: Park, Anna, et al.
Publicado: (2021)

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
por: Cantu, David, et al.
Publicado: (2009)

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)
por: Ben-Menachem, Reut, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n422mp7br313dl5uhp51oqhgp7