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Involvement of Ca(2+) in Signaling Mechanisms Mediating Muscarinic Inhibition of M Currents in Sympathetic Neurons

Acetylcholine can excite neurons by suppressing M-type (KCNQ) potassium channels. This effect is mediated by M(1) muscarinic receptors coupled to the G(q) protein. Although PIP(2) depletion and PKC activation have been strongly suggested to contribute to muscarinic inhibition of M currents (I(M)), d...

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Detalles Bibliográficos
Autores principales: Yoon, Jin-Young, Ho, Won-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287826/
https://www.ncbi.nlm.nih.gov/pubmed/36369494
http://dx.doi.org/10.1007/s10571-022-01303-7