Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation

Gastrulation begins when the epiblast forms the primitive streak or becomes definitive ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions in transcriptional activation and repression, but the mechanisms remain unclear. By converting mouse embryonic stem cells...

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Detalles Bibliográficos
Autores principales: van der Veer, Bernard K, Chen, Lehua, Custers, Colin, Athanasouli, Paraskevi, Schroiff, Mariana, Cornelis, Riet, Chui, Jonathan Sai-Hong, Finnell, Richard H, Lluis, Frederic, Koh, Kian Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287924/
https://www.ncbi.nlm.nih.gov/pubmed/37021585
http://dx.doi.org/10.1093/nar/gkad231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287924/
https://www.ncbi.nlm.nih.gov/pubmed/37021585
http://dx.doi.org/10.1093/nar/gkad231

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