Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1

ANKLE1 is a nuclease that provides a final opportunity to process unresolved junctions in DNA that would otherwise create chromosomal linkages blocking cell division. It is a GIY-YIG nuclease. We have expressed an active domain of human ANKLE1 containing the GIY-YIG nuclease domain in bacteria, that...

Descripción completa

Detalles Bibliográficos
Autores principales: Freeman, Alasdair D J, Déclais, Anne-Cécile, Wilson, Timothy J, Lilley, David M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287932/
https://www.ncbi.nlm.nih.gov/pubmed/37216589
http://dx.doi.org/10.1093/nar/gkad416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287932/
https://www.ncbi.nlm.nih.gov/pubmed/37216589
http://dx.doi.org/10.1093/nar/gkad416

Ejemplares similares