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Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1

ANKLE1 is a nuclease that provides a final opportunity to process unresolved junctions in DNA that would otherwise create chromosomal linkages blocking cell division. It is a GIY-YIG nuclease. We have expressed an active domain of human ANKLE1 containing the GIY-YIG nuclease domain in bacteria, that...

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Detalles Bibliográficos
Autores principales:	Freeman, Alasdair D J, Déclais, Anne-Cécile, Wilson, Timothy J, Lilley, David M J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287932/ https://www.ncbi.nlm.nih.gov/pubmed/37216589 http://dx.doi.org/10.1093/nar/gkad416

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