Cytoplasmic aggregation of mutant FUS causes multistep RNA splicing perturbations in the course of motor neuron pathology

Dysfunction of the RNA-binding protein (RBP) FUS implicated in RNA metabolism can cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Mutations affecting FUS nuclear localization can drive RNA splicing defects and stimulate the formation of non-amyloid inclusions in affec...

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Detalles Bibliográficos
Autores principales: Rezvykh, Alexander P, Ustyugov, Aleksey A, Chaprov, Kirill D, Teterina, Ekaterina V, Nebogatikov, Vladimir O, Spasskaya, Daria S, Evgen’ev, Michael B, Morozov, Alexey V, Funikov, Sergei Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287951/
https://www.ncbi.nlm.nih.gov/pubmed/37115004
http://dx.doi.org/10.1093/nar/gkad319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287951/
https://www.ncbi.nlm.nih.gov/pubmed/37115004
http://dx.doi.org/10.1093/nar/gkad319

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