KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing

Mitochondrial U-indel RNA editing in kinetoplastid protozoa is directed by trans-acting gRNAs and mediated by a holoenzyme with associated factors. Here, we examine the function of the holoenzyme-associated KREH1 RNA helicase in U-indel editing. We show that KREH1 knockout (KO) impairs editing of a...

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Detalles Bibliográficos
Autores principales: Dubey, Ashutosh P, Tylec, Brianna L, Mishra, Amartya, Sortino, Katherine, Chen, Runpu, Sun, Yijun, Read, Laurie K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287954/
https://www.ncbi.nlm.nih.gov/pubmed/37140035
http://dx.doi.org/10.1093/nar/gkad292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287954/
https://www.ncbi.nlm.nih.gov/pubmed/37140035
http://dx.doi.org/10.1093/nar/gkad292

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