Destabilized 3’UTR elements therapeutically degrade ERBB2 mRNA in drug-resistant ERBB2+ cancer models

Breast, lung, and colorectal cancer resistance to molecular targeted therapy is a major challenge that unfavorably impacts clinical outcomes leading to hundreds of thousands of deaths annually. In ERBB2+ cancers regardless of the tissue of origin, many ERBB2+ cancers are resistant to ERBB2-targeted...

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Detalles Bibliográficos
Autores principales: Awah, Chidiebere U., Glemaud, Yana, Levine, Fayola, Yang, Kiseok, Ansary, Afrin, Dong, Fu, Ash, Leonard, Zhang, Junfei, Ogunwobi, Olorunseun O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287955/
https://www.ncbi.nlm.nih.gov/pubmed/37359373
http://dx.doi.org/10.3389/fgene.2023.1184600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10287955/
https://www.ncbi.nlm.nih.gov/pubmed/37359373
http://dx.doi.org/10.3389/fgene.2023.1184600

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